Cutaneous adverse drug reactions induced by Oxcarbazepine
نویسندگان
چکیده
Poster background Oxcarbazepine (OXC) is a structural analog of carbamazepine (CBZ). OXC is considered a promising alternative medication for patients who cannot tolerate CBZ because of its equivalent clinical effiecacy and fewer cutaneous adverse drug reactions (cADRs) compared to CBZ. HLAB*15:02 allele was shown to strongly associate with carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) in Chinese and Southeast Asian populations.However,the epidemiological data about OXC-induced cADRs in recent years is limited. This study aims to investigate the clinical characteristics of OXC-induced cADRs and their genetic associations with HLA-B*15:02.
منابع مشابه
Desensitization to Oxcarbazepine: Long-Term Efficacy and Tolerability
BACKGROUND AND PURPOSE Antiepileptic drug (AED)-associated cutaneous adverse drug reactions can lead to the discontinuation of medications. The aim of this study was to determine the long-term efficacy and safety of performing desensitization to oxcarbazepine. METHODS This study involved 20 patients who exhibited cutaneous adverse drug reactions associated with oxcarbazepine use between July ...
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عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2014